Association of methionine synthase rs1801394 and methionine synthase reductase rs1805087 polymorphisms with meningioma in adults: A meta-analysis

abstract: ...Several epidemiological studies suggested that methionine synthase (MTRR) rs1801394 and methionine synthase reductase (MTR) rs1805087 polymorphisms may be involved in the risk of meningioma in adults; however, the results from different case-control studies have been inconsistent. Therefore, we performed a meta-analysis to investigate the association of MTRR and MTR polymorphisms with meningioma. PubMed, Web of Knowledge, China National Knowledge Infrastructure and Wanfang databases were searched up to October 30, 2013 and 3 publications, involving 7 case-control studies, were finally included. Following data extraction, a meta-analysis was conducted using Stata 12.0 software. The pooled results based on the fixed effects model demonstrated that the MTRR rs1801394 polymorphism was associated with an increased risk of meningioma [odds ratio (OR)=1.18, 95% confidence interval (CI): 1.051.32 for G vs. A; OR=1.41, 95% CI: 1.121.77 for GG vs. AA; OR=1.08, 95% CI: 0.941.33 for AG vs. AA; OR=1.19, 95% CI: 1.011.40 for (AG+GG) vs. AA; and OR=1.32, 95% CI: 1.071.63 for GG vs. (AG+AA)]; however, an association between the MTR rs1805087 polymorphism and the risk of meningioma was not identified [OR=0.99, 95% CI: 0.881.12 for G vs. A; OR=1.09, 95% CI: 0.801.48 for GG vs. AA; OR=0.95, 95% CI: 0.821.11 for AG vs. AA; OR=0.97, 95% CI: 0.841.13 for (AG+GG) vs. AA; and OR=1.09, 95% CI: 0.801.48 for GG vs. (AG+AA)]. Therefore, the currently available evidence suggests that the MTRR rs1801394 polymorphism may increase the risk of meningioma, whereas the MTRR rs1801394 polymorphism is not associated with meningioma.

...Biomed Rep Biomed Rep BR Biomedical Reports 2049-9434 2049-9442 D.A. Spandidos 24748989 3990204 10.3892/br.2014.248 br-02-03-0432 Articles Association of methionine synthase rs1801394 and methionine synthase reductase rs1805087 polymorphisms with meningioma in adults: A meta-analysis ZENG XIAN-TAO 1 * LU JUN-TI 2 * TANG XIANG-JUN 2 * WENG HONG 1 LUO JIE 1 2 1 Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China

... Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. Several epidemiological studies suggested that methionine synthase (MTRR) rs1801394 and methionine synthase reductase (MTR) rs1805087 polymorphisms may be involved in the risk of meningioma in adults; however, the results from different case-control studies have been inconsistent. Therefore, we performed a meta-analysis to

... meningioma [odds ratio (OR)=1.18, 95% confidence interval (CI): 1.051.32 for G vs. A; OR=1.41, 95% CI: 1.121.77 for GG vs. AA; OR=1.08, 95% CI: 0.941.33 for AG vs. AA; OR=1.19, 95% CI: 1.011.40 for (AG+GG) vs. AA; and OR=1.32, 95% CI: 1.071.63 for GG vs. (AG+AA)]; however, an association between the MTR rs1805087 polymorphism and the risk of meningioma was not identified [OR=0.99, 95% CI: 0.881.12 for G vs. A; OR=1.09, 95% CI: 0.801.48 for GG vs. AA; OR=0.95, 95% CI: 0.821.11 for AG vs. AA; OR=0.97, 95

.... The MTRR A66G (rs1801394) polymorphism is a well-recognized locus associated with enzyme function and may affect the interaction of MTRR and MTR, participating in tumor formation ( 20 ). A common polymorphism in MTR, A2756G (rs1805087), is considered to affect enzyme activity, leading to homocysteine elevation and DNA hypomethylation ( 21 ). Several molecular epidemiological studies have been conducted to investigate the association of MTRR rs1801394 and MTR rs1805087 polymorphisms with meningioma. Yu et al ( 22 ) performed a meta-analysis based on two publications and indicated that there was no association between the MTR rs1805087 polymorphism and meningioma; however, 3 years later, a primary study reporting an association between MTR rs1805087 and meningioma was published ( 23 ). Whether these results are altered by an updated meta-analysis requires clarification. Additionally, an association between the MTRR rs1801394 polymorphism and meningioma has not been confirmed. Therefore, we performed the present meta-analysis to investigate the association of the MTRR rs1801394 and MTR rs1805087 polymorphisms with susceptibility to meningioma. The present meta-analysis was conducted according to the Meta-analysis of Observational Studies in Epidemiology statements ( 24 ). Materials and methods Inclusion criteria A publication was included if it met the following criteria: i) the patients had been diagnosed with meningioma by magnetic resonance imaging, histological, pathological, or cytological methods; ii) the association of MTRR rs1801394 and/or MTR rs1805087 polymorphism with meningioma susceptibility was investigated; iii) the study design was a case-control study; iv) the number of individual genotypes in the case and control groups was provided or could be calculated using valid information; and v) the publication language was restricted to English or Chinese. Search strategy The PubMed, Web of Knowledge, China National Knowledge Infrastructure and Wanfang databases were

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