Even with diet and exercise, most people simply can't keep the weight off
Your body has a weight setpoint. When you lose fat, your metabolism decreases to preserve energy and prevent starvation. This is why most diets fail.
The body weight setpoint is real
Scientists have figured out how it works. It's in the brain.
In the brain, special neurons sense hormones and regulate metabolism and appetite. If you have too much fat, your brain directly signals your fat cells to release their energy.
It works like a fuel gauge. People gain excess fat when this gauge isn't sensitive enough.
By studying thousands of genomes, scientists have discovered several genes that regulate body weight. Many of the top obesity-associated genes are found in this exact part of the brain! Scientists who study these genes calculate that body weight is between 70% to 90% genetic.
People don't get fat due to gluttony and sloth
Diet and Exercise work, but genetics makes it much harder for some
Your health is a product of your genes and lifestyle. What if we had enough data to understand these complex relationships between genetics, diet, and exercise? Our open science movement hopes to accomplish this.