Sexy gene conversions: locating gene conversions on the X-chromosome

... consists of creating the zinc finger transcription factor that can regulate mRNA transcription. Two X-linked gene members of the subfamily, ZXDA and ZXDB , derive from a very ancient and highly conserved gene duplication event and are subject to X-inactivation ( 23 ). In the phylogenetic tree in Figure 8 , we can see that again we have a split by biological order. Furthermore, the genes appear to have very high similarity which is indicated by very short branch lengths. This high similarity could account for the similarity between the rat ZXDA gene and the mouse ZXDA gene. Unfortunately, we could not find a definitive rat ZXDA gene. Figure 8. PTHR19818:SF18 phylogenetic tree. The synteny graph in the Supplementary Data shows the locations of ZXDA and ZXDB in the human and mouse genome. The locations of these genes are similar for all species. Furthermore, these genes are relatively isolated across all species with other genes located further downstream and upstream by relatively large margins. GENECONV global and pairwise analyses show similar results; both identified gene conversions between ZXDA and ZXDB genes in the human, chimpanzee and mouse genomes ( Tables 1 and 2 ). Interestingly, predicted gene conversion lengths are long, with the human and chimpanzee genome having >450 bp, and the mouse genome having >1000 bp (pairwise analysis) and 2000 bp (global detection). The results from Partimatrix are consistent with the results of GENECONV, also suggesting gene conversions in the three

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Gene: ZXDB - zinc finger, X-linked, duplicated B - (NCBI)

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