Phylointeractomics reconstructs functional evolution of protein binding

... TERF1, TERF2 and HOT1 have been demonstrated to directly bind to double-stranded telomeric DNA while both POT1 and the CST complex are single-stranded telomere binders 17 18 19 . In addition to the established double-strand binders, we identified eight zinc finger proteins (ZBTB7A, ZBTB10, ZBTB48, ZNF276, ZNF524, ZNF827, VEZF1 and KLF12) enriched at the TTAGGG repeat sequence in at least five species. We speculate that some of these candidates bind double-stranded TTAGGG repeats directly and have functional roles at the telomere. For instance, human ZNF827 has, in the meantime, been reported to localize to telomeres, to induce telomere remodeling and to promote telomeretelomere recombination 20 . Consistently, with our observed enrichment of RECQL1 to TTAGGG repeats in 8 species, this helicase is involved in telomere maintenance, actively resolving telomeric D-loops and Holliday junction substrates, regulated via an interaction with TERF2 in human cells 21 . The recently discovered direct

... contributing to telomerase recruitment . EMBO J. 32 , 1681 1701 ( 2013 ). 23685356 Palm W. & de Lange T. How shelterin protects mammalian telomeres . Annu. Rev. Genet. 42 , 301 334 ( 2008 ). 18680434 Miyake Y. . RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway . Mol. Cell 36 , 193 206 ( 2009 ). 19854130 Conomos D. , Reddel R. R. & Pickett H. A. NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for

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Gene: ZNF827 - zinc finger protein 827 - (NCBI)

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