Identification of key genes for carcinogenic pathways associated with colorectal adenoma-to-carcinoma progression

... (proliferation); ADRM1 and NUDT1 (differentiation); SSSCA1, ID3 , LUM , FYCO1 , RFC3 , LOXL2 , SVIL , KIAA0367 , and NUDT1 (stroma activation); and SPARC , DCN , and PDGFRB (invasion). For the angiogenesis gene set, none of the individual genes passed the threshold for genome-wide significance. Table 2 lists all genes within the cancer-related processes that exhibited p values<1e-4. The magnitude of differential expression between colorectal adenomas and adenocarcinomas for genes from each of these processes, i.e., AURKA, PLK1 , ADRM1 , SSSCA1 , SPARC , and PDGFRB , is illustrated with boxplots (Fig. 1 ). Table2 Key genes in cancer-related processes associated with colorectal adenoma-to-carcinoma progression Cancer-related process, GO- or Exp-derived gene set Gene symbol p Value (Students t test with unequal variance) Chromosomal instability (Exp) AURKA 3.58 e-09 C20orf24 1.15 e-07 TPX2 2.60 e-06 TRIP13 1.32 e-05 ATAD2 1.80 e-05 CDCA3 1.88 e-05 UBE2C 2.55 e-05 CDC45L 6.40 e-05 AURKB 6.64 e-05 NEK2 6.95 e-05 NXT1 7.91 e-05 ASF1B 8.52 e-05 Proliferation (Exp) PLK1 5.93 e-06 CCNF 7.46 e-06 DNMT1 1.81 e-05 PKMYT1 3.00 e-05 AURKB 6.64 e-05 Differentiation (Exp) ADRM1 8.42 e-07 NUDT1 9.57 e-06 CENPA 1.05 e-05 TRIP13 1.32 e-05 UBE2C 2.55 e-05 MYBL2 5.62 e-05 Angiogenesis (GO) EREG 1.28 e-05 COL15A1 1.75 e-05 SERPINE1 9.07 e-05 Stroma activation (Exp) SSSCA1 9.25 e-09 ID3 1.09 e-08 LUM 5.69 e-08 FYCO1 2.63 e-07 RFC3 6.27 e-07 LOXL2 6.80 e-07 SVIL 1.50 e-06 KIAA0367 6.37 e-06 NUDT1 9.57 e-06 MYBL2 5.62

... pathways (in bold). Listed are the genes that exhibit p values<1e-4 GO gene ontology, Exp experiment Fig.1 Comparison of mRNA expression levels for key genes of pathway activity in colorectal adenomas and CRCs. Boxplots showing mRNA expression levels of 37 colorectal adenomas and 31 colorectal adenocarcinomas, based on oligonucleotide microarray expression data. Expression of key genes was significantly higher in CRC compared to adenomas ( p values<1e-5). a AURKA ; b PLK1 ; c ADRM1 ; d SSSCA1 ; e SPARC

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Gene: SSSCA1 - Sjogren syndrome/scleroderma autoantigen 1 - (NCBI)

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