Whole Brain Expression of Bipolar Disorder Associated Genes: Structural and Genetic Analyses

...-analysis of >11,000 BD cases and >51,000 controls [2] . Each SNP was examined to identify those that were associated (within 100 kb) of a single gene. Intergenic variants or SNPs in close proximity to multiple genes were excluded from further analyses. In this manner, 58 genes were selected for brain mapping ( Table 1 ). 10.1371/journal.pone.0100204.t001 Table 1 Genes in proximity to BD-associated SNPs. Gene Name ADCY2 FAM155A MSI2 SIPA1L2 AKAP13 FLJ16124 NFIX SNX8 ANK3 FSTL5 NGF SPERT ANKS1A GATA5

... regions are organized anatomically, by broadly defined regions where FC: frontal cortex, HP: hippocampus, TC: temporal cortex, A: amygdala ST: striatum, HY: hypothalamus, TH: thalamus, MB: midbrain, CB: cerebellum, PN: pontine nuclei, MD: medulla. 10.1371/journal.pone.0100204.t002 Table 2 Bipolar disorder associated gene expression clusters. Cluster 1 Cluster 2 Cluster 3 ATP6V1G3 ADCY2 ANK3 GATA5 CACNB3 STK39 GPR81 DLG2 FAM155A NGF KDM5B SIPA1L2 NPAS3 KIF1A PAX1 MAPK10 SPERT RIMBP2 TNR UBE2E3 ZMIZ1

... 2 KIF1A 0.29 0.24 0.16 0.80 2 MAPK10 0.81 0.58 0.69 0.80 2 RIMBP2 * 0.07 0.21 0.04 0.76 2 UBE2E3 0.85 0.61 0.79 0.73 2 UBR1 * 0.03 0.05 0.08 0.75 3 ANK3 0.69 0.63 0.72 0.64 3 FAM155A 0.67 0.69 0.59 0.70 3 SIPA1L2 0.76 0.49 0.65 0.63 3 STK39 0.43 0.36 0.29 0.68 *significant set-based association. **trend towards set-based association. There was no relationship between the strength of the SNPs BD-association in the index gene, and the subsequent set-based association. That is to say, SNPs strongly

... differences. For C1, 3/9 genes (33%) were mapped to M4, two were mapped to M3 (22%), one was mapped to M2 (11%), while the C1 gene GPR81 was not assigned to any module. For C2, 9/9 genes (100%) we assigned to M2. C3 corresponded to M1, but FAM155A , STK39 also showed correlation with M2, and SIPA1L2 was not categorized by WGCNA. We also checked the 58 BD associated genes for omissions from clusters that would be suggested using the WGCNA modules. In this way, C15orf53 (M4) could be categorized in C1; and

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Gene: SIPA1L2 - signal-induced proliferation-associated 1 like 2 - (NCBI)

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