Correlation of SASH1 expression and ultrasonographic features in breast cancer

abstract: ...Objective SASH1 is a member of the SH3/SAM adapter molecules family and has been identified as a new tumor suppressor and critical protein in signal transduction. An ectopic expression of SASH1 is associated with decreased cell viability of breast cancer. The aim of this study was to explore the association between SASH1 expression and the ultrasonographic features in breast cancer. Patients and methods A total of 186 patients diagnosed with breast cancer were included in this study. The patients received preoperative ultrasound examination, and the expression of SASH1 was determined using immunohistochemistry methods. Spearmans rank correlation analysis was used to analyze the correlation between SASH1-positive expression and the ultrasonographic features. Results The positive expression of SASH1 was observed in 63 (33.9%) patients. The positive expression rate of SASH1 was significantly decreased in patients with breast cancer (63/186, 33.9%) compared with controls ( P <0.001). The positive expression rate of SASH1 was significantly decreased in patients with edge burr sign ( P =0.025), lymph node metastasis ( P =0.007), and a blood flow grade of III ( P =0.013) compared with patients without those adverse ultrasonographic features. The expression of SASH1 was negatively correlated with edge burr sign ( P =0.025), lymph node metastasis ( P =0.007), and blood flow grade ( P =0.003) of the patients with breast cancer. Conclusion The expression of SASH1 was inversely correlated with some critical ultrasonographic features, including edge burr sign, lymph node metastasis, and blood flow grade in breast cancer, and decreased SASH1 expression appears to be associated with adverse clinical and imaging features in breast cancer.

...Onco Targets Ther Onco Targets Ther OncoTargets and Therapy OncoTargets and therapy 1178-6930 Dove Medical Press 28138250 5237597 10.2147/OTT.S119244 ott-10-271 Original Research Correlation of SASH1 expression and ultrasonographic features in breast cancer Gong Xuchu 1 Wu Jinna 1 Wu Jian 2 Liu Jun 2 Gu Hailin 1 Shen Hao 3 1 Department of Surgery 2 Department of Endocrinology 3 Department of Doppler Ultrasonic, Traditional Chinese Medicine Hospital of Nantong City, Nantong, Jiangsu, Peoples

... Creative Commons Attribution Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/ ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Objective SASH1 is a member of the SH3/SAM adapter molecules family and has been identified as a new tumor suppressor and critical protein in signal transduction. An ectopic expression of SASH1 is associated with decreased cell viability of breast cancer. The aim of this study was to explore the association between SASH1 expression and the ultrasonographic features in breast cancer. Patients and methods A total of 186 patients diagnosed with breast cancer were included in this study. The patients received preoperative ultrasound examination, and the expression of SASH1 was determined using immunohistochemistry methods. Spearmans rank correlation analysis was used to analyze the correlation between SASH1-positive expression and the ultrasonographic features. Results The positive expression of SASH1 was observed in 63 (33.9%) patients. The positive expression rate of SASH1 was significantly decreased in patients with breast cancer (63/186, 33.9%) compared with controls ( P <0.001). The positive expression rate of SASH1 was significantly decreased in patients with edge burr sign ( P =0.025), lymph node metastasis ( P =0.007), and a blood flow grade of III ( P =0.013) compared with patients without those adverse ultrasonographic features. The expression of SASH1 was negatively correlated with edge burr sign ( P =0.025), lymph node metastasis ( P =0.007), and blood flow grade ( P =0.003) of the patients with breast cancer. Conclusion The expression of SASH1 was inversely correlated with some critical ultrasonographic features, including edge burr sign, lymph node metastasis, and blood flow grade in breast cancer, and decreased SASH1 expression appears to be associated with adverse clinical and imaging features in breast cancer. Keywords SASH1 breast cancer ultrasound Introduction Breast cancer is one of the most common malignancies affecting women worldwide, and its initiation and development are affected by many factors. 1 , 2 Most patients have already been diagnosed in tumor progressing stage when visiting doctors, few of whom are noted in early tumor stage and receive treatment, which would have adverse effects on the patients prognosis. The current clinical therapy for treating breast cancer is mainly based on the estrogen receptor (ER) levels and pathological staging. 3 , 4 Analyzing the correlation between breast ultrasound imaging and specific protein expression in cancerous tissues could contribute to providing a valuable reference for patients postoperative treatment and prognosis. SASH1 is a member of SH3/SAM adapter molecules family and has been identified as a new tumor suppressor and critical protein in signal transduction. Ren et al 5

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Gene: SASH1 - SAM and SH3 domain containing 1 - (NCBI)

Protein : 2ebp

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