Methamphetamine Alters the Normal Progression by Inducing Cell Cycle Arrest in Astrocytes

... clustering in the Toll-like receptor pathway. (C) Genes downregulated by MA have a high clustering in the process of progression through the cell cycle and cell cycle regulation. 10.1371/journal.pone.0109603.t003 Table 3 Genes induced by repeated MA treatment found in the Lysosome compartment. WASH Complex [FAM21A, FAM21B, FAM21C] Endosomalpart [CD1D, CD63, CLCN6, EPHB1, FAM21A, FAM21B, FAM21C, HLA-DQB1, KIF16B, LAMP2, LDLR, NPC1, NTRK2, PRLR, SLC11A2, STEAP1, STEAP3, TF, TFRC] Endosomalmembrane [CD1D, CD63, CLCN6, EPHB1, FAM21A, FAM21B, FAM21C, HLA-DQB1, KIF16B, LAMP2, LDLR, NPC1, NTRK2, SLC11A2, STEAP1, STEAP3, TF, TFRC] EarlyEndosome [APOE, CD8B, CLN3, CTNS, EPHB1, FAM21A, FAM21B, FAM21C, KIF16B, LDLR, SLC11A2, TF] Vacuolarmembrane [AP1S2, CD1D, CD63, CLN3, CTNS, DRAM1, GBA, HLA-DQB1, IGF2R, LAMP2, M6PR, MAP1LC3C, NEU1, NPC1, SLC11A2, SLC17A5, SLC36A1] Lysosome [ADA, AP1S2, CD1D, CD63, CLN3, CST3, CTNS, CTSA, CTSC, DNASE2, DRAM1, FYCO1, GBA, GLB1, GM2A, GNS, HEXA, HEXB, HLA-DQB1, HPS1, IDS

..., BACE2, BST2, CD1D, CD63, CD8B, CDH1, CLCN6, CLN3, CST3, CTNS, EPHB1, EXPH5, FAM21A, FAM21B, FAM21C, FLT1, FYCO1, HLA-DQB1, IGF2R,KIF16B, LAMP2, LDLR, M6PR, NPC1, NTRK2, PIK3R4, PRLR, SLC11A2, SLC2A4, SQSTM1, 10.1371/journal.pone.0109603.t004 Table 4 Genes induced by repeated MA treatment have function in the innate immune reponse. Activation of the immune system [ADA, CFB, CXCL10, DUSP3, DUSP4, DUSP6, FOS, HLA-DQB1, IFIH1, JUN, LY96, LYN, MBL2, MICA, NR1D1, NR1H3, PRKCB, TLR1, TRAT1] Signal

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Gene: FAM21C - family with sequence similarity 21, member C - (NCBI)

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